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About This Item

Empirical Formula (Hill Notation):
C21H22FN3O · HCl · xH2O
CAS Number:
199673-74-0
Molecular Weight:
387.88 (anhydrous basis)
MDL number:
MFCD11519957
UNSPSC Code:
12352202
PubChem Substance ID:
329825086
NACRES:
NA.77
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Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H2O: ≥5 mg/mL (warmed)

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl.CN1CCC(CC1)c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23

InChI

1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H

InChI key

DGPDGAPZTPSHBL-UHFFFAOYSA-N

Application

LY-334370 hydrochloride hydrate may be used to study 5-HT 1F-mediated cell signaling.

Biochem/physiol Actions

LY-334370 hydrochloride is a selective 5-HT1F receptor agonist.
LY-334370 modulates the transmission in the mouse trigeminal system and inhibits the neuronal responses within rat Sp5C by inhibiting c-Fos activation. It shows efficacy in aborting migraine attacks.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
041M4626V

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