SML0021
PDI inhibitor 16F16
≥98% (HPLC)
Synonym(s):
2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
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About This Item
Empirical Formula (Hill Notation):
C16H17ClN2O3
CAS Number:
Molecular Weight:
320.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: 12 mg/mL, clear
storage temp.
2-8°C
SMILES string
COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl
InChI
1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
InChI key
BCSIRYFYAKLJDK-UHFFFAOYSA-N
Application
PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.
PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.
Biochem/physiol Actions
16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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