SML0022
IMB-10
≥98% (HPLC)
Synonym(s):
3-(2-methylphenyl)-5-(3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C19H15NOS2
CAS Number:
Molecular Weight:
337.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
UYZLENPCNZVWQZ-QHMSGILQSA-N
SMILES string
Cc1ccccc1N2C(=S)S\C(=C\C=C\c3ccccc3)C2=O
InChI
1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥25 mg/mL
storage temp.
2-8°C
Quality Level
Application
IMB-10 may be used to study integrin-mediated signaling in tumor cells.
Biochem/physiol Actions
IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.
IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.
Stabilizing Ligand of αMβ2 integrin
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Juho Suojanen et al.
Anticancer research, 27(6B), 3775-3781 (2008-01-30)
Leukocyte immunomodulation has great clinical potential as a therapy of inflammatory conditions and cancer. We have recently developed leukocyte alphaMbeta2 integrin targeting small molecule (IMB-10) capable of inhibiting leukocyte migration and recruitment in vitro and in vivo. The purpose of
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service