SML0022
IMB-10
≥98% (HPLC)
别名:
3-(2-methylphenyl)-5-(3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone
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关于此项目
经验公式（希尔记法）:
C19H15NOS2
化学文摘社编号:
分子量:
337.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
UYZLENPCNZVWQZ-QHMSGILQSA-N
SMILES string
Cc1ccccc1N2C(=S)S\C(=C\C=C\c3ccccc3)C2=O
InChI
1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥25 mg/mL
storage temp.
2-8°C
Quality Level
Application
IMB-10 may be used to study integrin-mediated signaling in tumor cells.
Biochem/physiol Actions
IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.
IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.
Stabilizing Ligand of αMβ2 integrin
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Juho Suojanen et al.
Anticancer research, 27(6B), 3775-3781 (2008-01-30)
Leukocyte immunomodulation has great clinical potential as a therapy of inflammatory conditions and cancer. We have recently developed leukocyte alphaMbeta2 integrin targeting small molecule (IMB-10) capable of inhibiting leukocyte migration and recruitment in vitro and in vivo. The purpose of
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