SML0047
MoTP
≥98% (HPLC)
Synonym(s):
33N14, 4-(4-Morpholinobutylthio)phenol
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About This Item
Empirical Formula (Hill Notation):
C14H21NO2S
CAS Number:
Molecular Weight:
267.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥80 mg/mL
storage temp.
−20°C
SMILES string
Oc1ccc(SCCCCN2CCOCC2)cc1
InChI
1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2
InChI key
YHKNLUTUXZDOQI-UHFFFAOYSA-N
Application
MoTP may be used in cell signaling and differentiation studies.
Biochem/physiol Actions
Melanocytotoxic; reversibly blocks the specification of neural crest cells into melanocytes
MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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