SML0050
CGP 37849
≥98% (HPLC)
Synonym(s):
(3E)-2-Amino-4-methyl-5-phosphono-3-pentanoic acid
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About This Item
Empirical Formula (Hill Notation):
C6H12NO5P
CAS Number:
Molecular Weight:
209.14
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
SMILES string
C\C(CP(O)(O)=O)=C/C(N)C(O)=O
InChI key
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: ≥2 mg/mL (warmed)
storage temp.
2-8°C
Quality Level
Application
CGP 37849 may be used in NMDA-mediated cell signaling studies.
Biochem/physiol Actions
CGP 37849 induces phencyclidine-like behavioral syndrome in amygdala-kindled rats that includes ataxia, locomotion and stereotypies.
CGP 37849 is a potent orally active competitive NMDA antagonist and anticonvulsant.
Potent orally active competitive NMDA antagonist and anticonvulsant.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A Y Gemperle et al.
Neuroscience, 117(3), 681-695 (2003-03-06)
The mode of action of the antipsychotic drugs clozapine, haloperidol and iloperidone was investigated in layer V of prefrontal cortex slices using extracellular field potential, intracellular sharp-electrode as well as whole-cell voltage clamp recording techniques. Intracellular investigations on a broad
K Wedzony et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 56(2), 205-221 (2005-06-30)
Malfunction of glutamatergic neurotransmission in postnatal period is considered to be a risk factor for development of schizophrenia. Thus, the present study investigates the impact of NMDA receptor blockade in the postnatal period on the density of tyrosine hydroxylase immunoreactive
Krzysztof Wedzony et al.
Pharmacological reports : PR, 60(6), 856-864 (2009-02-13)
Postnatal hypofunction of N-methyl-D-aspartate (NMDA) receptors leads to several behavioral deficits in adult rats resembling deficits typical of schizophrenia-like deficits of sensorimotor gating. Thus far, it is not known whether the above disruptions are sensitive to neuroleptic drugs. In order
Małgorzata Dybała et al.
Journal of neural transmission (Vienna, Austria : 1996), 115(11), 1519-1520 (2008-10-08)
The NMDA receptor antagonist, CGP 37849-induced reduction in immobility time in the forced swim test in mice was not antagonized by pre-treatment with the AMPA receptor antagonist NBQX. This is the first demonstration of the antidepressant effect of the NMDA
K Wedzony et al.
Neuroscience, 153(4), 1370-1379 (2008-04-25)
The malfunction of glutamatergic neurotransmission in the neonatal or postnatal periods may be a risk factor for the appearance of neuroanatomical, neurochemical or functional changes that are characteristic of schizophrenia. Thus, the present study was undertaken to investigate whether blockade
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