SML0050
CGP 37849
≥98% (HPLC)
别名:
(3E)-2-Amino-4-methyl-5-phosphono-3-pentanoic acid
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关于此项目
经验公式（希尔记法）:
C6H12NO5P
化学文摘社编号:
分子量:
209.14
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: ≥2 mg/mL (warmed)
storage temp.
2-8°C
SMILES string
C\C(CP(O)(O)=O)=C/C(N)C(O)=O
InChI
1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
InChI key
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
Application
CGP 37849 may be used in NMDA-mediated cell signaling studies.
Biochem/physiol Actions
CGP 37849 induces phencyclidine-like behavioral syndrome in amygdala-kindled rats that includes ataxia, locomotion and stereotypies.
CGP 37849 is a potent orally active competitive NMDA antagonist and anticonvulsant.
Potent orally active competitive NMDA antagonist and anticonvulsant.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A Y Gemperle et al.
Neuroscience, 117(3), 681-695 (2003-03-06)
The mode of action of the antipsychotic drugs clozapine, haloperidol and iloperidone was investigated in layer V of prefrontal cortex slices using extracellular field potential, intracellular sharp-electrode as well as whole-cell voltage clamp recording techniques. Intracellular investigations on a broad
K Wedzony et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 56(2), 205-221 (2005-06-30)
Malfunction of glutamatergic neurotransmission in postnatal period is considered to be a risk factor for development of schizophrenia. Thus, the present study investigates the impact of NMDA receptor blockade in the postnatal period on the density of tyrosine hydroxylase immunoreactive
K Wedzony et al.
Neuroscience, 153(4), 1370-1379 (2008-04-25)
The malfunction of glutamatergic neurotransmission in the neonatal or postnatal periods may be a risk factor for the appearance of neuroanatomical, neurochemical or functional changes that are characteristic of schizophrenia. Thus, the present study was undertaken to investigate whether blockade
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0050-5MG | 04061832074672 |
| SML0050-25MG | 04061832074665 |