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SML0054

Schizandrin

Name: Schizandrin
Brand: SIGMA

≥98% (HPLC), Antioxidant, powder

Synonym(s):

(+)-Schizandrin, Schisandrin, Schisandrine, Wuweizi alcohol A, Wuweizichun A

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₂O₇

CAS Number:

7432-28-2

Molecular Weight:

432.51

UNSPSC Code:

12352200

PubChem Substance ID:

329825121

NACRES:

NA.77

MDL number:

MFCD00905761

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Schizandrin, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 75 to 95°, c = 1 in methanol

color

white to beige

solubility

DMSO: ≥13 mg/mL

storage temp.

room temp

SMILES string

COc1cc2C[C@H](C)[C@@](C)(O)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC)c1OC

InChI

1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3/t13-,24-/m0/s1

InChI key

YEFOAORQXAOVJQ-RZFZLAGVSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Schizandrin may be used in oxidative stress-related cell signaling studies.

Biochem/physiol Actions

Antioxidant; Anti-inflammatory, reduces oxidative stress.

Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000525269

0000398387

0000398385

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Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity.

Si-Yuan Pan et al.

Lipids in health and disease, 11, 120-120 (2012-09-20)

Schisandra, a globally distributed plant, has been widely applied to health care products. Here, we investigated the effects of dietary intake of Fructus Schisandrae chinensis (FSC), both aqueous and ethanolic extracts (AqFSC, EtFSC), on serum/hepatic lipid contents in normal diet

Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons.

Shih-Hung Yang et al.

Journal of the science of food and agriculture, 91(4), 694-702 (2011-02-09)

Schisandra chinensis, commonly used in Asia for tea material and traditional Chinese medicine, is presumed to enhance mental and intellectual functions. In this study, the effects and signalling mechanisms of a purified compound schisandrin, one of the lignan of Schisandra

Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages.

Sun Young Park et al.

Immunology letters, 139(1-2), 93-101 (2011-06-08)

The lipopolysaccharide (LPS) of Porphyromonas gingivalis is thought to induce periodontitis. In this study, we isolated Schisandrin from the dried fruits of Schisandra chinensis and examined the anti-inflammatory effect of Schisandrin in macrophages stimulated with LPS from P. gingivalis. First

Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems.

Bing Shao et al.

Drug development and industrial pharmacy, 36(11), 1356-1363 (2010-09-21)

Wurenchun is the alcohol extract from Fructus Schisandrae Chinensis, which has good efficiency in lowering abnormal serum glutamic pyruvic transaminase (SGPT) level of patients suffering from acute or chronic hepatitis. The main purpose of this work is to prepare self-emulsifying

Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum.

Jia-Ming Yang et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(13), 1153-1160 (2011-07-19)

In this study, the herbal extracts of Schisandra chinensis were demonstrated to inhibit the contractions induced by acetylcholine (ACh) and serotonin (5-HT) in guinea pig ileum, and the 95% ethanol extract was more effective than the aqueous extract. Analysis with

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Global Trade Item Number

SKU	GTIN
SML0054-10MG	04061832723235
SML0054-50MG	04061832723242

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