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SML0057

Camostat mesylate

Name: Camostat mesylate
Brand: SIGMA

≥98% (HPLC), Serine protease inhibitor, powder

Synonym(s):

4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₂N₄O₅·CH₃SO₃H

CAS Number:

59721-29-8

Molecular Weight:

494.52

UNSPSC Code:

12352203

PubChem Substance ID:

329825123

NACRES:

NA.77

MDL number:

MFCD00941410

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Camostat mesylate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H₂O: ≥24 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(N)=N)cc2)cc1

InChI

1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

InChI key

FSEKIHNIDBATFG-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Camostat mesylate has been used to determine the effect of transmembrane protease, serine (TMPRSS) family proteases on cell-cell fusion.

Camostat mesylate may be used in cell signaling studies.

Biochem/physiol Actions

Camostat is a serine protease inhibitor, airway epithelial sodium channel (ENaC) attenuator.

Camostat is a synthetic, orally bioavailble serine protease inhibitor and airway epithelial sodium channel (ENaC) attenuator.

Camostat mesylate (CM) is used to treat pancreatitis and reflux esophagitis after gastrectomy.

Camostat mesylate inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes. It also inhibits the activity of pancreatic stellate cells. Camostat mesylate regulates the cytokine expression and inflammation and is effective in the treatment of dibutyltin dichloride-induced rat pancreatic fibrosis.

Features and Benefits

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H315,H319,H335,H400

pcodes

P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000539657

0000101221

101M4745V

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Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity.

Junya Gibo et al.

Laboratory investigation; a journal of technical methods and pathology, 85(1), 75-89 (2004-11-09)

Camostat mesilate (CM), an oral protease inhibitor, has been used clinically for the treatment of chronic pancreatitis in Japan. However, the mechanism by which it operates has not been fully understood. Our aim was to evaluate the therapeutic efficacy of

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization.

Hannah Kleine-Weber et al.

Journal of virology, 93(2) (2018-11-09)

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a threat to public health. The virus is endemic in the Middle East but can be transmitted to other countries by travel activity. The introduction of MERS-CoV into the Republic of Korea by

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry.

Yushun Wan et al.

Journal of virology, 94(5) (2019-12-13)

Antibody-dependent enhancement (ADE) of viral entry has been a major concern for epidemiology, vaccine development, and antibody-based drug therapy. However, the molecular mechanism behind ADE is still elusive. Coronavirus spike protein mediates viral entry into cells by first binding to

Cell Entry of Porcine Epidemic Diarrhea Coronavirus Is Activated by Lysosomal Proteases.

Chang Liu et al.

The Journal of biological chemistry, 291(47), 24779-24786 (2016-10-13)

Porcine epidemic diarrhea coronavirus (PEDV) is currently devastating the United States pork industry by causing an 80-100% fatality rate in infected piglets. Coronavirus spike proteins mediate virus entry into cells, a process that requires the spike proteins to be proteolytically

Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2.

Jie Hu et al.

Genes & diseases, 7(4), 551-557 (2020-08-25)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative virus of the coronavirus disease 2019 (COVID-19) pandemic. To establish a safe and convenient assay system for studying entry inhibitors and neutralizing antibodies against SARS-CoV-2, we constructed a codon-optimized, full-length

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Global Trade Item Number

SKU	GTIN
SML0057-10MG	04061833221631
SML0057-50MG	04061833221648

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