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SML0063

Q-VD-OPh hydrate

Name: Q-VD-OPh hydrate
Brand: SIGMA

≥95% (HPLC), powder, pan-caspase inhibitor

Synonym(s):

5-(2,6-Difluorophenoxy)-3-[[3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₅F₂N₃O₆ · xH₂O

CAS Number:

1435786-01-8

Molecular Weight:

513.49 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329825128

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Q-VD-OPh hydrate, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: ≥14 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

O=C(NC(C(C)C)C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)=O)C2=NC3=CC=CC=C3C=C2.[H]O[H]

InChI

1S/C26H25F2N3O6.H2O/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28;/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34);1H2/t20-,23-;/m0./s1

InChI key

ONOTWLLTFZMERH-WCRWPNQISA-N

Description

Application

Q-VD-OPh hydrate has been used:

as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
to induce canonical caspase-dependent apoptosis in UC cells
to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells

Biochem/physiol Actions

Pan-caspase inhibitor.

Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c