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Merck
CN

SML0066

Sigma-Aldrich

NGB 2904 hydrochloride

≥98% (HPLC)

Synonym(s):

N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C28H29Cl2N3O·HCl
CAS Number:
189061-11-8
Molecular Weight:
530.92
MDL number:
MFCD09971107
UNSPSC Code:
12352200
PubChem Substance ID:
329825130
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl

InChI

1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H

InChI key

PFIWYJNBKGCVFM-UHFFFAOYSA-N

Application

NGB 2904 hydrochloride may be used in cell signaling studies.

Biochem/physiol Actions

Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.
NGB 2904 hydrochloride is a potent and selective dopamine D3 receptor antagonist
NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000210937
0000210937
061M4617V
0000140999
0000128878

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Laurel M Pritchard et al.
Pharmacology, biochemistry, and behavior, 86(4), 718-726 (2007-04-06)
The dopamine D3 receptor is believed to play an important role in regulation of rodent locomotor behavior, and has been proposed as a therapeutic target for substance abuse, psychotic disorders, and Parkinson's disease. One model of dopamine D3 receptor function

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