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SML0066

NGB 2904 hydrochloride

≥98% (HPLC)

Synonym(s):

N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C28H29Cl2N3O·HCl
CAS Number:
189061-11-8
Molecular Weight:
530.92
NACRES:
NA.77
PubChem Substance ID:
329825130
UNSPSC Code:
12352200
MDL number:
MFCD09971107
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl

InChI

1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H

InChI key

PFIWYJNBKGCVFM-UHFFFAOYSA-N

Application

NGB 2904 hydrochloride may be used in cell signaling studies.

Biochem/physiol Actions

Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.
NGB 2904 hydrochloride is a potent and selective dopamine D3 receptor antagonist
NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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