SML0088
WZ811
≥98% (HPLC)
Synonym(s):
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
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About This Item
Empirical Formula (Hill Notation):
C18H18N4
CAS Number:
Molecular Weight:
290.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥7 mg/mL
storage temp.
2-8°C
SMILES string
C(Nc1ccccn1)c2ccc(CNc3ccccn3)cc2
InChI
1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)
InChI key
KBVFRXIGQQRMEF-UHFFFAOYSA-N
Biochem/physiol Actions
WZ811 is a CXCR4 Antagonist
WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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