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Merck
CN

SML0095

Conessine

≥97% (HPLC)

Synonym(s):

(3β)-N,N-dimethyl-con-5-enin-3-amine, Conessin, NSC 119994, Neriine, Roquessine, Wrightine

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About This Item

Empirical Formula (Hill Notation):
C24H40N2
CAS Number:
546-06-5
Molecular Weight:
356.59
NACRES:
NA.77
PubChem Substance ID:
329825153
UNSPSC Code:
12352200
EC Number:
208-897-2
MDL number:
MFCD00016752

Key Documents

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InChI key

GPLGAQQQNWMVMM-MYAJQUOBSA-N

InChI

1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1

SMILES string

C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C

assay

≥97% (HPLC)

form

powder

color

white to tan

solubility

ethanol: ≥2 mg/mL

originator

Abbott

storage temp.

2-8°C

Quality Level

100

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General description

Conessine is a steroidal alkaloid. It has anti-malarial properties, thus, conessine has been used in treatment of malaria.

Biochem/physiol Actions

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. The molecule also binds to the human α2C4 adrenergic receptor (pKi = 7.98).
H3 receptor antagonist

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000184672
0000184673
0000184673
0000184672
052M4708V

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[On a new acquisition in phytotherapy: Holarrhena floribunda and its principal alkaloid: conessine].
R PARIS
Gazette medicale de France, Spec. No., 79-83 (1951-12-01)
[New therapy of intestinal amebiasis].
G HONIGSBERG
Le Medecin generaliste de France, 11(12), 227-228 (1951-12-01)
[Conessine in the treatment of vaginitis due to Trichomonas].
A SICARD et al.
La Presse medicale, 58(48), 853-853 (1950-07-29)
[Experimental studies of conessine. Comparative study of the culture medium of dysenteric amoeba after addition of chlorhydrates of conessine or emetine].
M PIETTE
Annales pharmaceutiques francaises, 8(5), 402-409 (1950-05-01)
[Distribution and fixation time of conessine in the organs of the monkey].
C AUFFRET et al.
Medecine tropicale : revue du Corps de sante colonial, 10(3), 530-536 (1950-05-01)
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