SML0121
BTZO-1
≥98% (HPLC)
Synonym(s):
2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one
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About This Item
Empirical Formula (Hill Notation):
C13H8N2OS
CAS Number:
Molecular Weight:
240.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥7 mg/mL
originator
Takeda
storage temp.
2-8°C
SMILES string
O=C1N=C(Sc2ccccc12)c3ccccn3
InChI
1S/C13H8N2OS/c16-12-9-5-1-2-7-11(9)17-13(15-12)10-6-3-4-8-14-10/h1-8H
InChI key
GBAKVEWPYUIGHN-UHFFFAOYSA-N
Application
BTZO-1 may be used in ARE-mediated gene expression studies.
Biochem/physiol Actions
BTZO-1 is a suppressor of cardiomyocyte apoptosis presumably by activation of antioxidant response element (ARE)-mediated gene expression. BTZO-1 binds to the macrophage migration inhibitory factor (MIF) that is required to activate the glutathione S-transferase Ya subunit (GST Ya) gene ARE.
suppressor of cardiomyocyte apoptosis; ligand of macrophage migration inhibitory factor (MIF)
Features and Benefits
This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0121-5MG | 04061832723273 |
| SML0121-25MG | 04061832260600 |