SML0146
ZL006
≥98% (HPLC)
Synonym(s):
4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
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About This Item
Empirical Formula (Hill Notation):
C14H11Cl2NO4
CAS Number:
Molecular Weight:
328.15
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥5 mg/mL (warmed to 60° C)
storage temp.
2-8°C
SMILES string
OC1=C(Cl)C=C(Cl)C=C1CNC(C=C2)=CC(O)=C2C(O)=O
InChI
1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)
InChI key
RTEYSQSXRFVKTJ-UHFFFAOYSA-N
Biochem/physiol Actions
ZL006, a novel neuroprotectant, is also called as 5-(3, 5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid. It has the ability to block the interaction of neuronal nitric oxide synthase (nNOS)/postsynaptic density protein-95 (PSD-95) in co-immunoprecipitation assays of extracts from glutamate or cultured neurons and cortical brain, stimulated by ischemia.
Inhibitor of nNOS-PSD-95 interaction
ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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