SML0151
CCT036477
Synonym(s):
α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine
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About This Item
Empirical Formula (Hill Notation):
C21H18ClN3
CAS Number:
Molecular Weight:
347.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
Quality Segment
form
powder
color
white to tan
solubility
DMSO: ≥20 mg/mL (warm to 60°C)
storage temp.
−20°C
SMILES string
Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4
InChI
1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
InChI key
IFOHRIXRQPOHQZ-UHFFFAOYSA-N
Biochem/physiol Actions
CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
Wnt β-catenin antagonist
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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