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SML0151

CCT036477

Synonym(s):

α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine

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About This Item

Empirical Formula (Hill Notation):
C21H18ClN3
CAS Number:
305372-78-5
Molecular Weight:
347.84
NACRES:
NA.77
PubChem Substance ID:
329825199
UNSPSC Code:
12352200
MDL number:
MFCD01831143
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥20 mg/mL (warm to 60°C)

storage temp.

−20°C

SMILES string

Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4

InChI

1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)

InChI key

IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Biochem/physiol Actions

CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
Wnt β-catenin antagonist

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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