SML0173
Reversan
≥98% (HPLC)
Synonym(s):
CBLC4H10, N-[3-(4-Morpholinyl)propyl]-5,7-diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C26H27N5O2
CAS Number:
Molecular Weight:
441.52
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
faintly yellow to yellow
solubility
DMSO: ≥8 mg/mL at ~60 °C
storage temp.
2-8°C
SMILES string
O=C(NCCCN1CCOCC1)c2cnn3c(cc(nc23)-c4ccccc4)-c5ccccc5
InChI
1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32)
InChI key
JTRXWCLQFAZHGP-UHFFFAOYSA-N
Application
Reversan may be used in cell signaling studies.
Biochem/physiol Actions
Nontoxic MRP1 function inhibitor; MRP1 and Pgp function inhibitor; multidrug transporter inhibitor
Reversan increases the efficacy of vincristine and etoposide and increases the sensitivity of murine models of neuroblastoma to conventional chemotherapy.
Reversan is a selective and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp) inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Catherine A Burkhart et al.
Cancer research, 69(16), 6573-6580 (2009-08-06)
The multidrug resistance-associated protein 1 (MRP1) has been closely linked to poor treatment response in several cancers, most notably neuroblastoma. Homozygous deletion of the MRP1 gene in primary murine neuroblastoma tumors resulted in increased sensitivity to MRP1 substrate drugs (vincristine
Isabel Koh et al.
Communications biology, 7(1), 177-177 (2024-02-29)
With the advent of increasingly sophisticated organoids, there is growing demand for technology to replicate the interactions between multiple tissues or organs. This is challenging to achieve, however, due to the varying culture conditions of the different cell types that
Michelle J Henderson et al.
Journal of the National Cancer Institute, 103(16), 1236-1251 (2011-07-30)
Although the prognostic value of the ATP-binding cassette, subfamily C (ABCC) transporters in childhood neuroblastoma is usually attributed to their role in cytotoxic drug efflux, certain observations have suggested that these multidrug transporters might contribute to the malignant phenotype independent
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0173-25MG | 04061833221976 |
| SML0173-5MG | 04061833221983 |