SML0173
Reversan
≥98% (HPLC)
别名:
CBLC4H10, N-[3-(4-Morpholinyl)propyl]-5,7-diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide
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关于此项目
经验公式（希尔记法）:
C26H27N5O2
化学文摘社编号:
分子量:
441.52
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
faintly yellow to yellow
solubility
DMSO: ≥8 mg/mL at ~60 °C
storage temp.
2-8°C
SMILES string
O=C(NCCCN1CCOCC1)c2cnn3c(cc(nc23)-c4ccccc4)-c5ccccc5
InChI
1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32)
InChI key
JTRXWCLQFAZHGP-UHFFFAOYSA-N
Application
Reversan may be used in cell signaling studies.
Biochem/physiol Actions
Nontoxic MRP1 function inhibitor; MRP1 and Pgp function inhibitor; multidrug transporter inhibitor
Reversan increases the efficacy of vincristine and etoposide and increases the sensitivity of murine models of neuroblastoma to conventional chemotherapy.
Reversan is a selective and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp) inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable