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Merck
CN

SML0178

Sigma-Aldrich

ARL-17477 dihydrochloride hydrate

≥98% (HPLC)

Synonym(s):

N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C20H20ClN3S·2HCl · xH2O
CAS Number:
866914-87-6
Molecular Weight:
442.83 (anhydrous basis)
MDL number:
MFCD21608518
UNSPSC Code:
12352202
PubChem Substance ID:
329825207
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: ≥5 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1

InChI

1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2

InChI key

QOPATWWWZNTSQF-UHFFFAOYSA-N

Related Categories

Application

ARL-17477 dihydrochloride hydrate may be used in cell signaling studies.

Biochem/physiol Actions

ARL-17477 dihydrochloride hydrate is a selective nNOS inhibitor
ARL-17477 is an nNOS specific inhibitor. The IC50 against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000157695
012M4606V
0000054139
0000014645

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