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SML0187

CJ-13610

Name: CJ-13610
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₃N₃O₂S

CAS Number:

179420-17-8

Molecular Weight:

393.50

NACRES:

NA.77

PubChem Substance ID:

329825216

UNSPSC Code:

51111800

MDL number:

MFCD00948114

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2

InChI

1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)

InChI key

VPTONMHDLLMOOV-UHFFFAOYSA-N

Description

Application

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

Biochem/physiol Actions

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC₅₀ = 70 nM).

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.

Potent 5-lipoxygenase inhibitor

Features and Benefits

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Articles

Leukotriene Receptors

We offer many products related to leukotriene receptors for your research needs.

Prostanoid Receptors

We offer many products related to prostanoid receptors for your research needs.

Discover Bioactive Small Molecules for Lipid Signaling Research

Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.

Raquel Horrillo et al.

The Journal of pharmacology and experimental therapeutics, 323(3), 778-786 (2007-09-04)

In this study, we examined the relative contribution of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO), two major proinflammatory pathways up-regulated in liver disease, to the progression of hepatic inflammation and fibrosis. Separate administration of 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-236), a selective COX-2 inhibitor, and

Global Trade Item Number

SKU	GTIN
SML0187-25MG	04061832786407
SML0187-5MG	04061832786414

Key Documents

CJ-13610

≥98% (HPLC)

Select a Size

About This Item

Quality Level

assay

form

storage condition

color

solubility

storage temp.

SMILES string

InChI

InChI key

Application

Biochem/physiol Actions

Features and Benefits

Safety Information

Storage Class

flash_point_f

flash_point_c

Regulatory Information

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Protocols and Articles

Articles

Peer Reviewed Papers

Global Trade Item Number