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Merck
CN

SML0199

Metaxalone

≥98% (HPLC)

Synonym(s):

5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone, 5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone, AHR 438, Metaxalon, Metazalone, Metazolone, NSC 170959

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About This Item

Empirical Formula (Hill Notation):
C12H15NO3
CAS Number:
1665-48-1
Molecular Weight:
221.25
NACRES:
NA.77
PubChem Substance ID:
329825224
UNSPSC Code:
12352200
EC Number:
216-777-6
MDL number:
MFCD00867700

Key Documents

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InChI key

IMWZZHHPURKASS-UHFFFAOYSA-N

InChI

1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)

SMILES string

Cc1cc(C)cc(OCC2CNC(=O)O2)c1

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥2 mg/mL (warmed to 60 °C)

storage temp.

−20°C

Quality Level

100

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Application

Metaxalone may be used in cell signaling studies.

Biochem/physiol Actions

Metaxalone is a muscle relaxant. The mechanism of action of metaxalone in humans is not fully understood. It was suggested that it acts through general central nervous system depression.
Metaxalone is effective to relieve pain due to acute skeletal muscle pain caused due to musculoskeletal conditions and sprains.
Muscle relaxant (skeletal)

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000506949
0000506949
0000435888
0000435888
0000137124

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Justin L Poklis et al.
Journal of analytical toxicology, 28(6), 537-541 (2004-11-02)
The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatography-mass spectrometry were used to determine the following drug concentrations (mg/L) in aortic blood: 19 mg/L metaxalone;
Rakshit Kanubhai Trivedi et al.
Scientia pharmaceutica, 80(2), 353-366 (2012-08-17)
A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination of metaxalone (META) in pharmaceutical dosage forms. The method is applicable to the quantification of
Peter P Toth et al.
Clinical therapeutics, 26(9), 1355-1367 (2004-11-09)
Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support. The aim of this review was to discuss the etiology of low back pain and the relative risks and

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