SML0203
iCRT14
≥98% (HPLC), Wnt / β-catenin pathway inhibitor, powder
Synonym(s):
5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione
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About This Item
Empirical Formula (Hill Notation):
C21H17N3O2S
CAS Number:
Molecular Weight:
375.44
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
iCRT14, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cc(\C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4
InChI
1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChI key
NCSHZXNGQYSKLR-UNOMPAQXSA-N
Application
iCRT14 may be used in Wnt /β-catenin-mediated cell signaling studies.
Biochem/physiol Actions
Wnt / beta-catenin pathway inhibitor
iCRT14 belongs to the thiazolidinedione class of β-catenin-responsive transcription inhibitors. It decreases the levels of Dishevelled protein and modulates the binding of T-cell factor (TCF) to DNA. It results in consistent decrease in reduction of cell proliferation and tumor growth in colon cancer cells.
iCRT14 is a Wnt / β-catenin pathway inhibitor. It is a potent inhibitor of Catenin Responsive Transcription (CRT) reporter genes, as well as endogenous gene targets. iCRT14 also disrupts β-catenin-TCF4 interaction in a dose dependent manner, and causes G0/G1 arrest in colon tumor lines.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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