SML0208
KYP-2047
≥95% (HPLC), Prolyl oligopeptidase inhibitor, oil
Synonym(s):
(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
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About This Item
Empirical Formula (Hill Notation):
C20H25N3O2
CAS Number:
Molecular Weight:
339.43
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
oil
Storage condition:
desiccated
Product Name
KYP-2047, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
oil
storage condition
desiccated
color
white to light brown
storage temp.
2-8°C
SMILES string
O=C(CCCc1ccccc1)N2CCC[C@H]2C(=O)N3CCC[C@H]3C#N
InChI
1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
InChI key
SPXFAUXQZWJGCJ-ROUUACIJSA-N
Application
KYP-2047 may be used in prolyl endopeptidase-mediated cell signaling studies.
Biochem/physiol Actions
KYP-2047 clears the α-synuclein aggregates induced by oxidative stress in the neuronal cells. α-synuclein is the main component of Lewy bodies in Parkinson′s disease that cause neuronal cell death and dementia.
KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine).
KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 has been found to be neuroprotective against glutamate and oxygen, glucose deprivation in vitro. It has also been used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.
Features and Benefits
This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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