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SML0220

YM 022

≥98% (HPLC)

Synonym(s):

N-[(3R)-2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N′-(3-methylphenyl)-urea

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About This Item

Empirical Formula (Hill Notation):
C32H28N4O3
CAS Number:
145084-28-2
Molecular Weight:
516.59
NACRES:
NA.77
PubChem Substance ID:
329825239
UNSPSC Code:
12352200
MDL number:
MFCD00917023
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +128 to +140 (c = 1, DCM)

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

room temp

SMILES string

Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c4ccccc4N(CC(=O)c5ccccc5C)C2=O)c1

InChI

1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1

InChI key

YCXFHPUBGMMWJQ-PMERELPUSA-N

Biochem/physiol Actions

YM022 is a very potent, selective antagonist of the gastrin/cholecystokinin (CCK)-B receptor. The Ki value for CCKB is 68 pM vs 63 nM for CCKA. In rats, YM022 inhibits pentagastrin-induced gastric emptying with an ED50 or 7.8 nM/kg.
YM022 is a very potent, selective antagonist of the gastrin/cholecystokinin (CCK)-B receptor.

Features and Benefits

This compound is featured on the Cholecystokinin and Gastrin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000438064
0000438064
0000426479
0000426479
0000156429

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D Chen et al.
Cell and tissue research, 299(1), 81-95 (2000-02-02)
The ECL cells in the oxyntic mucosa of rat stomach produce histamine and chromogranin A-derived peptides such as pancreastatin. The cells respond to gastrin via cholecystokinin-2 (CCK2) receptors. A CCK2 receptor blockade was induced by treatment (for up to 8
M Kitano et al.
British journal of pharmacology, 130(3), 699-705 (2000-05-24)
Histamine-forming ECL cells in the rat stomach operate under the control of gastrin. They represent a convenient target for studying cholecystokinin-B/gastrin (CCK(2)) receptor antagonists in vivo. We examined the effectiveness and duration of action of two CCK(2) antagonists, YM022 and
Soo Yeun Lee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10993-11002 (2011-07-29)
Parvalbumin-positive (PV+) fast-spiking basket cells are thought to play key roles in network functions related to precise time keeping during behaviorally relevant hippocampal synchronous oscillations. Although they express relatively few receptors for neuromodulators, the highly abundant and functionally important neuropeptide
S Attoub et al.
Endocrinology, 140(10), 4406-4410 (1999-09-28)
In the present study, we investigated whether cholecystokinin (CCK) or its structurally related peptide gastrin participates in long term regulation of adipocyte leptin secretion. The levels of circulating leptin observed after 2 and 6 h of refeeding in 18-h fast
Kazuhiro Imatake et al.
Journal of gastroenterology, 44(5), 396-404 (2009-03-20)
Capsaicin has beneficial pharmacological properties, such as the ability to improve appetite and digestion. However, capsaicin has been reported to suppress gastric acid output, but to increase secretion; no consensus as to its effects on gastric acid output has been
View All Related Papers

Global Trade Item Number

SKUGTIN
SML0220-25MG04061832948928
SML0220-5MG04061832948935

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