SML0222
TVP1022
≥98% (HPLC)
Synonym(s):
(1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine, (S)-Rasagiline, S-(-)-N-Propargyl-1-aminoindan
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About This Item
Empirical Formula (Hill Notation):
C12H13N
CAS Number:
Molecular Weight:
171.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
(Powder, Film or Oil)
Quality Segment
assay
≥98% (HPLC)
form
(Powder, Film or Oil)
solubility
DMSO: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
C#CCN[C@H]1CCc2ccccc12
InChI
1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
InChI key
RUOKEQAAGRXIBM-LBPRGKRZSA-N
Biochem/physiol Actions
TVP1022 is an S-isomer of rasagiline, a PKC Pathway activator and neuroprotective and cytoprotective
TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in rat models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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