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Safety Information

SML0270

Sigma-Aldrich

NSC 632839

≥98% (HPLC)

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Synonym(s):
3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride, 4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride, F6
Empirical Formula (Hill Notation):
C21H21NO · HCl
CAS Number:
157654-67-6
Molecular Weight:
339.86
MDL number:
MFCD09753281
PubChem Substance ID:
329825278

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥2 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

Cl.Cc1ccc(cc1)\C=C2/CNC\C(=C/c3ccc(C)cc3)C2=O

InChI

1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11+,20-12+;

InChI key

ZOKZLTXPTLIWOJ-BYCVLTJGSA-N

Biochem/physiol Actions

NSC 632839 is an ubiquitin isopeptidases inhibitor targets the ubiquitinproteasome system (UPS).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Marie-Louise Hessel et al.
Fertility and sterility, 105(2), 308-314 (2015-10-24)
To study whether immunohistochemical detection of germ cell neoplasia in situ (GCNIS) in AgarCytos, made of the remnants of the testicular sperm extraction (TESE) specimen, is equally accurate as in a standard testicular biopsy. Prospective cohort study performed between January
Ben Lewis et al.
Alcoholism, clinical and experimental research, 40(12), 2519-2527 (2016-10-16)
Driver age and blood alcohol concentration are both important factors in predicting driving risk; however, little is known regarding the joint import of these factors on neural activity following socially relevant alcohol doses. We examined age and alcohol effects on
Naif AlJohani et al.
Leukemia & lymphoma, 59(9), 2211-2219 (2017-12-19)
Although generally indolent, follicular lymphoma (FL) sometimes pursues a more aggressive course leading to early death. B-cell-specific Mo-MLV insertion site-1 (BMI1) is a member of the polycomb group (PcG) proteins that confer stem cell properties through gene silencing. We used
Harry Bulstrode et al.
Genes & development, 31(8), 757-773 (2017-05-04)
Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of these
Shaojie Yang et al.
Frontiers in microbiology, 8, 2583-2583 (2018-01-10)
Yeast cell-surface display technologies have been widely applied in the fields of food, medicine, and feed enzyme production, including lipase, α-amylase, and endoglucanase. In this study, a
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