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SML0271

VER-155008

Name: VER-155008
Brand: SIGMA

≥98% (HPLC), Hsp70 inhibitor, powder

Synonym(s):

5′-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₃Cl₂N₇O₄

CAS Number:

1134156-31-2

Molecular Weight:

556.40

UNSPSC Code:

12352200

PubChem Substance ID:

329825279

NACRES:

NA.77

MDL number:

MFCD18086892

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Product Name

VER-155008, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12

InChI

1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1

InChI key

ZXGGCBQORXDVTE-UMCMBGNQSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:

to study its effects on human embryonic kidney 293 (HEK293T) cells
to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells
to determine its effects on the attenuation of seizures in rats

Biochem/physiol Actions

VER-155002 is a Hsp70 inhibitor.

VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC₅₀ = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.

VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000497968

0000424837

0000369191

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Hsp90 is involved in pseudorabies virus virion assembly via stabilizing major capsid protein VP5.

Wen-Jing Zhang et al.

Virology, 553, 70-80 (2020-11-27)

Many viruses utilize molecular chaperone heat shock protein 90 (Hsp90) for protein folding and stabilization, however, the role of Hsp90 in herpesvirus lifecycle is obscure. Here, we provide evidence that Hsp90 participates in pseudorabies virus (PRV) replication. Viral growth kinetics

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.

Eunmi Lee et al.

Oncogene, 38(4), 469-482 (2018-09-01)

TNFα is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNFα exerts its diverse effects on breast cancer subtypes remains

Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease.

Ximeng Yang et al.

Frontiers in pharmacology, 9, 48-48 (2018-02-15)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in structural brain changes and memory impairment. We hypothesized that reconstructing neural networks is essential for memory recovery in AD. Heat shock cognate 70 (HSC70), a member of the heat shock

GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.

Miriam Schäfer et al.

FEBS letters, 591(21), 3567-3587 (2017-09-28)

The shedding of ectodomains is a crucial mechanism in many physiological and pathological events. A disintegrin and metalloprotease-17 (ADAM17) is a key sheddase involved in essential processes, such as development, regeneration, and immune defense. ADAM17 exists in two conformations which

VER-155008, a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung cancer cell lines.

Wei Wen et al.

Experimental biology and medicine (Maywood, N.J.), 239(5), 638-645 (2014-03-29)

Lung cancer is the most common malignancy and exhibits significant morbidity and mortality worldwide. Among all lung cancer subtypes, non-small-cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. Although there have been intensive investigations on the

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Global Trade Item Number

SKU	GTIN
SML0271-25MG	04061832723365
SML0271-5MG	04061837084034

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