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SML0271

VER-155008

Name: VER-155008
Brand: SIGMA

≥98% (HPLC), Hsp70 inhibitor, powder

Synonym(s):

5′-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₃Cl₂N₇O₄

CAS Number:

1134156-31-2

Molecular Weight:

556.40

UNSPSC Code:

12352200

PubChem Substance ID:

329825279

NACRES:

NA.77

MDL number:

MFCD18086892

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

VER-155008, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12

InChI

1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1

InChI key

ZXGGCBQORXDVTE-UMCMBGNQSA-N

Description

Application

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:

to study its effects on human embryonic kidney 293 (HEK293T) cells
to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells
to determine its effects on the attenuation of seizures in rats

Biochem/physiol Actions

VER-155002 is a Hsp70 inhibitor.

VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC₅₀ = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.

VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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