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Merck
CN

SML0280

(2′Z)-Indirubin

≥98% (HPLC)

Synonym(s):

3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one; [Δ2,3′-Biindoline]-2′,3-dione (7CI,8CI), C.I. 73200, Couroupitine B, Indigo red, Indigopurpurin, NSC 105327

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About This Item

Empirical Formula (Hill Notation):
C16H10N2O2
CAS Number:
Molecular Weight:
262.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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InChI

1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-

SMILES string

O=C1Nc2ccccc2\C1=C3\Nc4ccccc4C3=O

InChI key

CRDNMYFJWFXOCH-YPKPFQOOSA-N

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

Biochem/physiol Actions

Indirubin is an inhibitor of GSK-3β and specific AHR ligand.
Indirubin is an inhibitor of GSK-3β and of cyclin-dependent kinases (CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p35). Also, indirubin is a specific Aryl Hydrocarbon receptor (AHR) ligand.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Articles

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

肝醣合成酶激酶3 (GSK-3)是一种高度保守的丝氨酸/苏氨酸激酶家族,适于在多种途径中处理100多种蛋白质。查看允许的GSK-3调节剂和相关产品列表。

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