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SML0283

Amorolfine hydrochloride

≥98% (HPLC), Ergosterol biosynthesis inhibitor, powder

Synonym(s):

(2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride, Ro 14-4767/002

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About This Item

Empirical Formula (Hill Notation):
C21H35ON · HCl
CAS Number:
78613-38-4
Molecular Weight:
353.97
UNSPSC Code:
12352200
PubChem Substance ID:
329825291
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Product Name

Amorolfine hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: ≥5 mg/mL (warmed)

storage temp.

room temp

SMILES string

Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1

InChI

1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;

InChI key

XZKWIPVTHGWDCF-KUZYQSSXSA-N

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Application

Amorolfine hydrochloride has been used as an antifungal agent.

Biochem/physiol Actions

Amorolfine hydrochloride is a potential for treating onychomycosis infected nails by topical application. A 5% solution combination with fluconazole is effective on sensitive fungus in fingernail onychomycosis.
Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.
Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000530265
0000530265
0000523416
0000523416
0000414876

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Yuji Tabata et al.
Antimicrobial agents and chemotherapy, 60(2), 1035-1039 (2015-12-09)
Fungal nail infection (onychomycosis) is a prevalent disease in many areas of the world, with a high incidence approaching 23%. Available antifungals to treat the disease suffer from a number of disadvantages, necessitating the discovery of new efficacious and safe
A randomized, double-blind study of amorolfine 5\% nail lacquer with oral fluconazole compared with oral fluconazole alone in the treatment of fingernail onychomycosis
Chandra S, et al.
Indian Journal of Dermatology, 64(4), 253-253 (2019)
Production of Trichophyton rubrum microspores in large quantities and its application to evaluate amorolfine/azole compound interactions in vitro
Laurent A and Monod M
Mycoses, 60(9), 581-586 (2017)
Amorolfine
Haria M and BrysonHM
Drugs, 49(1), 103-120 (1995)
Sho Takahata et al.
Antimicrobial agents and chemotherapy, 60(2), 873-880 (2015-11-26)
Despite the existing treatment options for onychomycosis, there remains a strong demand for potent topical medications. ME1111 is a novel antifungal agent that is active against dermatophytes, has an excellent ability to penetrate human nails, and is being developed as
View All Related Papers

Global Trade Item Number

SKUGTIN
SML0283-10MG04061832633145
SML0283-50MG04061832633152

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