SML0334
DMPQ dihydrochloride
≥98% (HPLC)
Synonym(s):
5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H14N2O2 · 2HCl
CAS Number:
Molecular Weight:
339.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: >10 mg/mL
storage temp.
room temp
SMILES string
Cl.Cl.COc1cc(OC)c2cc(cnc2c1)-c3ccncc3
InChI
1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H
InChI key
YBBAOKYVJCNJIV-UHFFFAOYSA-N
Biochem/physiol Actions
DMPQ is a potent selective PDGFR inhibitor.
DMPQ is a potent selective inhibitor of human vascular beta-type platelet derived growth factor receptor tyrosine kinase (PDGFR?) with IC50 = 80 nM. It is > 100-fold selective over EGFR, erbB2, p56, protein kinase A and protein kinase C.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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