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Merck
CN

SML0334

DMPQ dihydrochloride

≥98% (HPLC)

Synonym(s):

5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H14N2O2 · 2HCl
CAS Number:
1123491-15-5
Molecular Weight:
339.22
NACRES:
NA.77
PubChem Substance ID:
329825339
UNSPSC Code:
12352200
MDL number:
MFCD02262123

Key Documents

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InChI

1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H

SMILES string

Cl.Cl.COc1cc(OC)c2cc(cnc2c1)-c3ccncc3

InChI key

YBBAOKYVJCNJIV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: >10 mg/mL

storage temp.

room temp

Quality Level

100

Related Categories

Biochem/physiol Actions

DMPQ is a potent selective PDGFR inhibitor.
DMPQ is a potent selective inhibitor of human vascular beta-type platelet derived growth factor receptor tyrosine kinase (PDGFR?) with IC50 = 80 nM. It is > 100-fold selective over EGFR, erbB2, p56, protein kinase A and protein kinase C.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000027973
0000027972
052M4724V

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Wafa Altalhi et al.
Biomaterials, 119, 23-32 (2016-12-19)
Cell-based tissue engineering is a potential treatment alternative for organ replacement. However, the lack of a robust vasculature, especially in the context of diseases such as diabetes, is a major hindrance to its success. Despite extensive research on the effects
Akshaya Srinivasan et al.
Biomaterials, 167, 153-167 (2018-03-24)
Mesenchymal stem cells (MSCs) have been isolated from various mesodermal and ectodermal tissues. While the phenotypic and functional heterogeneity of MSCs stemming from their developmental origins has been acknowledged, the genetic and environmental factors underpinning these differences are not well-understood.

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