SML0341
Importazole
≥98% (HPLC), importin-β transport receptor inhibitor, powder
Synonym(s):
N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
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About This Item
Empirical Formula (Hill Notation):
C20H22N4
CAS Number:
Molecular Weight:
318.42
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Importazole, ≥98% (HPLC)
SMILES string
CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4
InChI
1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)
InChI key
HKGJEZIGDHFJFL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >5 mg/mL
storage temp.
2-8°C
Quality Level
Related Categories
Application
Importazole has been used:
- to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
- to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
- as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
- as a functional inhibitor of Importin β in embryo treatment
- as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS
Biochem/physiol Actions
Importazole is an inhibitor of importin-β transport receptors.
Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Abeta accumulation via enhancement of ERK phosphatase VHR activity
Song H, et al.
Scientific reports, 6, 38452-38452 (2016)
High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4alpha and leads to hepatic steatosis in mice
Yu D, et al.
Journal of Cellular Physiology, 233(6), 4770-4782 (2018)
Essential elements for translation: the germline factor Vasa functions broadly in somatic cells
Yajima M and Wessel GM
Development, 142(11), 1960-1970 (2015)
Mutant p53 gains its function via c-Myc activation upon CDK4 phosphorylation at serine 249 and consequent PIN1 binding
Liao P, et al.
Molecular Cell, 68(6), 1134-1146 (2017)
Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder
Yun CY, et al.
Theranostics, 9(3), 646-646 (2019)
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