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SML0345

A 887826

≥98% (HPLC)

Synonym(s):

5-(4-butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-3-pyridinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C26H29ClN4O3
CAS Number:
1266212-81-0
Molecular Weight:
480.99
NACRES:
NA.77
PubChem Substance ID:
329825349
UNSPSC Code:
12352200
MDL number:
MFCD20926345
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

CCCCOc1ccc(cc1Cl)-c2cncc(c2)C(=O)NCc3cccnc3N4CCOCC4

InChI

1S/C26H29ClN4O3/c1-2-3-11-34-24-7-6-19(15-23(24)27)21-14-22(17-28-16-21)26(32)30-18-20-5-4-8-29-25(20)31-9-12-33-13-10-31/h4-8,14-17H,2-3,9-13,18H2,1H3,(H,30,32)

InChI key

JPJGFWKHSMUKFO-UHFFFAOYSA-N

Biochem/physiol Actions

A-887826 is Nav1.8 channel blocker (IC50 = 11 nM) that blocks TTX-resistant sodium currents in rat dorsal root ganglion in a voltage dependent fashion. Oral administration of A-887826 to rats significantly attenuated tactile allodynia in a neuropathic pain model.
Nav1.8 channel blocker

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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