SML0350
AZD-7762 hydrochloride
≥98% (HPLC)
Synonym(s):
5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C17H19FN4O2S · HCl
CAS Number:
Molecular Weight:
398.88
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to light brown
solubility
DMSO: 15 mg/mL, clear
storage temp.
−20°C
SMILES string
Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3
InChI
1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1
InChI key
WFZBLOIXZRZEDG-YDALLXLXSA-N
Application
AZD-7762 hydrochloride has been used:
- as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
- as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
- as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development
Biochem/physiol Actions
AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.
AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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