Key Documents

View All Documentation

SML0362

NPS2143 hydrochloride

Name: NPS2143 hydrochloride
Brand: SIGMA

≥98% (HPLC), Calcium-sensing receptor antagonist, powder

Synonym(s):

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1), NPS-2143 hydrochloride, SB-262470-A hydrochloride

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₅ClN₂O₂ · HCl

CAS Number:

324523-20-8

Molecular Weight:

445.38

UNSPSC Code:

12352200

PubChem Substance ID:

329825364

NACRES:

NA.77

MDL number:

MFCD16038896

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

NPS2143 hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]20/D +20 to +24°, c = 1.0 in methanol

storage condition

desiccated

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N

InChI

1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1

InChI key

ZEBNDUQLNGYBNL-VEIFNGETSA-N

Related Categories

Bioactive Small Molecules

Application

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

In the regulation of intestinal calcium transport.
In the regulation of local negative feedback of intestinal calcium absorption.
In sensorimotor decision making during development.

Biochem/physiol Actions

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302 + H312 + H332,H410

pcodes

P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Stanniocalcin 2 is upregulated by calcium-sensing receptor and protects human vascular smooth muscle cells from high phosphate-induced apoptosis.

Fen-Fen Liu et al.

Cardiorenal medicine (2022-10-11)

Introduction Apoptosis of vascular smooth muscle cells induced by hyperphosphatemia is a critical mechanism of chronic kidney disease-related vascular disorders. The present study investigated whether extracellular calcium-sensing receptor (CaSR) regulates stanniocalcin 2 (STC2) expression in HAoSMCs in vitro and whether

A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making

Jain RA, et al.

Current Biology, 28(9), 1357-1369 (2018)

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing receptor (CaSR) mutation: relevance to autosomal dominant hypocalcemia type 1 (ADH1)

Hannan FM, et al.

Endocrinology, 156(9), 3114-3121 (2015)

Progress in Medicinal Chemistry, 57 (2018)

Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors

Letz S, et al.

The Journal of Clinical Endocrinology and Metabolism, 95(10), E229-E233 (2010)

View All Related Papers

Global Trade Item Number

SKU	GTIN
SML0362-5MG	04061837084386
SML0362-25MG	04061833222546

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service