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Merck
CN

SML0363

DIM-C-pPhtBu

≥96% (HPLC)

Synonym(s):

1,1-Bis(3-indolyl)-1-(p-t-butylphenyl)methane, 3,3′-[[4-(1,1-Dimethylethyl)phenyl]methylene]bis-1H-indole

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About This Item

Empirical Formula (Hill Notation):
C27H26N2
CAS Number:
94944-80-6
Molecular Weight:
378.51
NACRES:
NA.77
PubChem Substance ID:
329825365
UNSPSC Code:
12352200
EC Number:
305-658-5
MDL number:
MFCD18082348

Key Documents

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InChI key

NCPVEZRBHNDCIV-UHFFFAOYSA-N

InChI

1S/C27H26N2/c1-27(2,3)19-14-12-18(13-15-19)26(22-16-28-24-10-6-4-8-20(22)24)23-17-29-25-11-7-5-9-21(23)25/h4-17,26,28-29H,1-3H3

SMILES string

CC(C)(C)c1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45

assay

≥96% (HPLC)

form

powder

storage condition

desiccated

color

light orange to dark orange

solubility

DMSO: >15 mg/mL

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

DIM-C-pPhtBu induces apoptosis in various cancer cell lines; induces endoplasmic reticulum (ER) stress in KB cancer cells.
DIM-C-pPhtBu, similar to other C-DIMs, exhibits a broad range of anticancer and antitumorigenic activities against multiple tumor types. DIM-C-pPhtBu causes apoptotic cell death of KB cells by activation of endoplasmic reticulum stress through induction of CHOP protein that is associated with the apoptosis in human oral cancer cells. Also it appears to induce an autophagic cell death in drug-resistant ER-negative breast tumors.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
052M4615V

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Sung Un Kang et al.
Cancer letters, 504, 23-36 (2021-02-09)
Despite technological advances in cancer treatment, the survival rate of patients with head and neck cancer (HNC) has not improved significantly. Many studies have shown that endoplasmic reticulum (ER) stress-related signals are associated with mitochondrial damage and that these signals

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