SML0363
DIM-C-pPhtBu
≥96% (HPLC)
别名:
1,1-Bis(3-indolyl)-1-(p-t-butylphenyl)methane, 3,3′-[[4-(1,1-Dimethylethyl)phenyl]methylene]bis-1H-indole
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关于此项目
经验公式（希尔记法）:
C27H26N2
CAS Number:
分子量:
378.51
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥96% (HPLC)
表单
powder
储存条件
desiccated
颜色
light orange to dark orange
溶解性
DMSO: >15 mg/mL
储存温度
−20°C
SMILES字符串
CC(C)(C)c1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45
InChI
1S/C27H26N2/c1-27(2,3)19-14-12-18(13-15-19)26(22-16-28-24-10-6-4-8-20(22)24)23-17-29-25-11-7-5-9-21(23)25/h4-17,26,28-29H,1-3H3
InChI key
NCPVEZRBHNDCIV-UHFFFAOYSA-N
生化/生理作用
DIM-C-pPhtBu induces apoptosis in various cancer cell lines; induces endoplasmic reticulum (ER) stress in KB cancer cells.
DIM-C-pPhtBu, similar to other C-DIMs, exhibits a broad range of anticancer and antitumorigenic activities against multiple tumor types. DIM-C-pPhtBu causes apoptotic cell death of KB cells by activation of endoplasmic reticulum stress through induction of CHOP protein that is associated with the apoptosis in human oral cancer cells. Also it appears to induce an autophagic cell death in drug-resistant ER-negative breast tumors.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Sung Un Kang et al.
Cancer letters, 504, 23-36 (2021-02-09)
Despite technological advances in cancer treatment, the survival rate of patients with head and neck cancer (HNC) has not improved significantly. Many studies have shown that endoplasmic reticulum (ER) stress-related signals are associated with mitochondrial damage and that these signals
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