SML0363
DIM-C-pPhtBu
≥96% (HPLC)
别名:
1,1-Bis(3-indolyl)-1-(p-t-butylphenyl)methane, 3,3′-[[4-(1,1-Dimethylethyl)phenyl]methylene]bis-1H-indole
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关于此项目
经验公式（希尔记法）:
C27H26N2
化学文摘社编号:
分子量:
378.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
305-658-5
MDL number:
InChI key
NCPVEZRBHNDCIV-UHFFFAOYSA-N
InChI
1S/C27H26N2/c1-27(2,3)19-14-12-18(13-15-19)26(22-16-28-24-10-6-4-8-20(22)24)23-17-29-25-11-7-5-9-21(23)25/h4-17,26,28-29H,1-3H3
SMILES string
CC(C)(C)c1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45
assay
≥96% (HPLC)
form
powder
storage condition
desiccated
color
light orange to dark orange
solubility
DMSO: >15 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
DIM-C-pPhtBu induces apoptosis in various cancer cell lines; induces endoplasmic reticulum (ER) stress in KB cancer cells.
DIM-C-pPhtBu, similar to other C-DIMs, exhibits a broad range of anticancer and antitumorigenic activities against multiple tumor types. DIM-C-pPhtBu causes apoptotic cell death of KB cells by activation of endoplasmic reticulum stress through induction of CHOP protein that is associated with the apoptosis in human oral cancer cells. Also it appears to induce an autophagic cell death in drug-resistant ER-negative breast tumors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sung Un Kang et al.
Cancer letters, 504, 23-36 (2021-02-09)
Despite technological advances in cancer treatment, the survival rate of patients with head and neck cancer (HNC) has not improved significantly. Many studies have shown that endoplasmic reticulum (ER) stress-related signals are associated with mitochondrial damage and that these signals
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