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SML0371

MLR-1023

≥98% (HPLC), Lyn kinase activator, powder

Synonym(s):

5-(3-Methylphenoxy)- 2(1H)-pyrimidinone, CP 26154, NSC 314335, Tolimidone

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About This Item

Empirical Formula (Hill Notation):
C11H10N2O2
CAS Number:
41964-07-2
Molecular Weight:
202.21
UNSPSC Code:
12352200
PubChem Substance ID:
329825372
NACRES:
NA.77
MDL number:
MFCD00866900
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Product Name

MLR-1023, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

room temp

SMILES string

Cc1cccc(OC2=CNC(=O)N=C2)c1

InChI

1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)

InChI key

HJQILFPVRNHTIG-UHFFFAOYSA-N

Biochem/physiol Actions

MLR-1023 has a therapeutic potential to treat type 2 diabetes.
MLR-1023 is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase that produces lasting glucose lowering, reduces HbA1c levels, and preserves pancreatic β-cells in db/db mice. MLR-1023 increased insulin receptor sensitivity. MLR-1023 (Tolimidone) is antiulcer agent.
MLR-1023 is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase; insulin receptor-potentiating agent; antiulcer agent.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000416627
0000416626
0000416626
0000416627
0000345345

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Articles

InsR

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Src Family Kinases Overview

Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Michael S Saporito et al.
The Journal of pharmacology and experimental therapeutics, 342(1), 15-22 (2012-04-05)
2(1H)-pyrimidinone,5-(3-methylphenoxy) (MLR-1023) is a candidate for the treatment of type 2 diabetes. The current studies were aimed at determining the mechanism by which MLR-1023 mediates glycemic control. In these studies, we showed that MLR-1023 reduced blood glucose levels without increasing
Fei Zhuang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(10), 13586-13596 (2020-08-29)
Endothelial microparticles (EMPs) are involved in various cardiovascular pathologies and play remarkable roles in communication between endothelial cells (ECs), which are constantly exposed to mechanical cyclic stretch (CS) following blood pressure. However, the roles of EMPs induced by CS in

Global Trade Item Number

SKUGTIN
SML0371-5MG04061833222577
SML0371-25MG04061833222560