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Merck
CN

SML0378

Sigma-Aldrich

Ralfinamide mesylate

≥98% (HPLC)

Synonym(s):

(2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C17H19FN2O2 · CH3SO3H
CAS Number:
202825-45-4
Molecular Weight:
398.45
MDL number:
MFCD19690932
UNSPSC Code:
12352200
PubChem Substance ID:
329825378
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 10 to 15° (c=1 HOAc)

color

white to beige

solubility

H2O: >15 mg/mL

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O

InChI

1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-6-8-15(9-7-13)22-11-14-4-2-3-5-16(14)18;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1

InChI key

CHQVNINIGBRKGZ-YDALLXLXSA-N

Biochem/physiol Actions

Ralfinamide is a mixed sodium and N-type calcium channel blocker.
Ralfinamide is a mixed sodium and N-type calcium channel blocker. Inhibiton is voltage-dependent, with higher potency against inactivated channels. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000496723
0000496723
0000288082
0000288082
0000132505

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Articles

Calcium Channels

We offers many products related to calcium channels for your research needs.

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

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