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Merck
CN

SML0400

ML204

≥98% (HPLC)

Synonym(s):

4-Methyl-2-(1-piperidinyl)-quinoline

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About This Item

Empirical Formula (Hill Notation):
C15H18N2
CAS Number:
5465-86-1
Molecular Weight:
226.32
NACRES:
NA.77
PubChem Substance ID:
329825396
UNSPSC Code:
12352200
MDL number:
MFCD00817920

Key Documents

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InChI

1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3

SMILES string

Cc1cc(nc2ccccc12)N3CCCCC3

InChI key

USYRQXDHKXGTCK-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL at warmed (clear solution)

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

4-methyl-2-(1- piperidinyl)-quinoline (ML204) has been used to attenuate Ewing sarcoma (EWS)-FLI1 activity in TC32 cells. It has also been used to attenuate scratching behavior evoked by α-Me-5HT in mice.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000209604
0000209604
0000102029
0000073392
0000026630

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Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells
Caropreso V, et al.
The Journal of Biological Chemistry, 291(19), 10058-10066 (2016)
Ruizhi Zhang et al.
Polymers, 12(2) (2020-02-08)
In this study, we fabricated poly (methyl methacrylate) (PMMA) microcellular foams featuring tunable cellular structures and porosity, through adjusting the supercritical CO2 foaming conditions. Experimental testing and finite element model (FEM) simulations were conducted to systematically elucidate the influence of
H M-H Chin et al.
Journal of helminthology, 91(4), 470-478 (2016-06-11)
Terrestrial arthropods host a variety of helminth parasites, yet quantifying the intensity of infection in these hosts post-mortem is challenging because carcasses may desiccate quickly. We recovered cysticercoids of Hymenolepis diminuta from desiccated flour beetle (Tribolium confusum) carcasses by modifying
Laura Bernal et al.
Science advances, 7(13) (2021-03-28)
Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular
Yun Zhu et al.
Chemico-biological interactions, 260, 84-90 (2016-11-08)
Aflatoxins are fungal metabolites which pose a major threat to food safety. Although these mycotoxins are established hepatocarcinogens, their effect on the reproductive organ is unknown. Transient Receptor Potential Channels (TRPs) are ubiquitously expressed in human tissues, including the placenta.
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