SML0421
SB265610
≥98% (HPLC)
Synonym(s):
1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea, N-(2-Bromophenyl)-N′-(7-cyano-1H-benzotriazol-4-yl)urea, SB 265610
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About This Item
Empirical Formula (Hill Notation):
C14H9BrN6O
CAS Number:
Molecular Weight:
357.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
SMILES string
Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23
InChI
1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChI key
SEDUMQWZEOMXSO-UHFFFAOYSA-N
Application
SB265610 has been used:
- as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR)
- as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells
- as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain
Biochem/physiol Actions
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist.
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
Features and Benefits
This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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