SML0444
Pluripotin
≥98% (HPLC)
Synonym(s):
N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide, SC 1, SC-1
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About This Item
Empirical Formula (Hill Notation):
C27H25F3N8O2
CAS Number:
Molecular Weight:
550.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
CN1C(=O)N(Cc2cnc(Nc3cc(C)nn3C)nc12)c4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C
InChI
1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
InChI key
NBZFRTJWEIHFPF-UHFFFAOYSA-N
Biochem/physiol Actions
Pluripotin is an activator of murine embryonic stem (ES) cell renewal; Dual RasGAP and ERK1 inhibitor.
Pluripotin is an activator of murine embryonic stem (ES) cell self-renewal. It appears that pluripotin mediates the activity by dual RasGAP and ERK1 inhibition.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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