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Merck
CN

SML0448

URB937

≥95% (HPLC)

Synonym(s):

Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester

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About This Item

Empirical Formula (Hill Notation):
C20H22N2O4
CAS Number:
1357160-72-5
Molecular Weight:
354.40
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

N(C3CCCCC3)C(=O)Oc1cc(c(cc1)O)c2cc(ccc2)C(=O)N

InChI

1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)

InChI key

CMEQHOXCIGFZNJ-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder (1:1 ratio of product to ethanol)

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

URB937 is a fatty acid amide hydrolase (FAAH) inhibitor that is actively excluded from the CNS by the membrane transporter ABCG2. The ED50 for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.
URB937 is a fatty acid amide hydrolase (FAAH) inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000130521
0000130522
0000130185
0000072232
0000072231

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