SML0448
URB937
≥95% (HPLC)
Synonym(s):
Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester
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About This Item
Empirical Formula (Hill Notation):
C20H22N2O4
CAS Number:
Molecular Weight:
354.40
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder (1:1 ratio of product to ethanol)
Quality Segment
assay
≥95% (HPLC)
form
powder (1:1 ratio of product to ethanol)
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
−20°C
SMILES string
N(C3CCCCC3)C(=O)Oc1cc(c(cc1)O)c2cc(ccc2)C(=O)N
InChI
1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)
InChI key
CMEQHOXCIGFZNJ-UHFFFAOYSA-N
Biochem/physiol Actions
URB937 is a fatty acid amide hydrolase (FAAH) inhibitor that is actively excluded from the CNS by the membrane transporter ABCG2. The ED50 for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.
URB937 is a fatty acid amide hydrolase (FAAH) inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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