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SML0450

5-BDBD

Name: 5-BDBD
Brand: SIGMA

≥98% (HPLC), P2X4 inhibitor, powder

Synonym(s):

5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₁BrN₂O₂

CAS Number:

768404-03-1

Molecular Weight:

355.19

UNSPSC Code:

12352200

PubChem Substance ID:

329824730

NACRES:

NA.77

MDL number:

MFCD18086878

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

5-BDBD, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

Brc1cccc(c1)C2=NCC(=O)Nc3c2oc4ccccc34

InChI

1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)

InChI key

NKYMVQPXXTZHSF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

5-BDBD is a specific inhibitor of P2X4.

5-BDBD is a specific inhibitor of P2X4. The compound inhibits P2X4 currents in CHO cells with an IC₅₀ of 500 nM.

In native tissues, 5-BDBD is considered as a beneficial antagonist to analyze the effect of P2X receptors (P2XRs) subtype P2X4R.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

P2 Receptors: P2X Ion Channel Family

We offer many products related to P2X ion channel family receptors for your research needs.

P2受体：P2X离子通道家族

我们可提供多种P2X离子通道受体相关产品，满足您的各类研究需求。

A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells.

Yun-Ming Tu et al.

Food & function, 8(12), 4336-4346 (2017-09-25)

Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses

P2rx4 deficiency in mice alleviates allergen-induced airway inflammation.

Andreas Zech et al.

Oncotarget, 7(49), 80288-80297 (2016-11-20)

Compelling evidences point out a crucial role for extracellular nucleotides such as adenosine triphosphate (ATP) during inflammatory conditions. Once released into the extracellular space, ATP modulates migration, maturation and function of various inflammatory cells via activating of purinergic receptors of

5-BDBD ameliorates an OVA-induced allergic asthma by the reduction of Th2 cytokines production.

Bing Hu et al.

Iranian journal of basic medical sciences, 21(4), 364-369 (2018-05-26)

P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice. Ovalbumin was used to sensitize

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Global Trade Item Number

SKU	GTIN
SML0450-25MG	04061832075754
SML0450-5MG	04061837084577