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Merck
CN

SML0461

PH-002

≥98% (HPLC)

Synonym(s):

4-[[4-[[2-(3,4-Dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester, PH 002, PH002

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About This Item

Empirical Formula (Hill Notation):
C27H33N5O4
CAS Number:
1311174-68-1
Molecular Weight:
491.58
NACRES:
NA.77
PubChem Substance ID:
329824739
UNSPSC Code:
12352200
MDL number:
MFCD22666400

Key Documents

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Quality Level

100

InChI

1S/C27H33N5O4/c1-27(2,3)36-26(35)32-15-13-31(14-16-32)18-19-9-11-20(12-10-19)28-24(33)17-23-21-7-5-6-8-22(21)25(34)30(4)29-23/h5-12H,13-18H2,1-4H3,(H,28,33)

SMILES string

O=C(N1CCN(CC2=CC=C(NC(CC3=NN(C)C(C4=C3C=CC=C4)=O)=O)C=C2)CC1)OC(C)(C)C

InChI key

GSXXTLWPQMHHDJ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

Related Categories

Biochem/physiol Actions

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that restores mitochondrial cytochrome c oxidase subunit 1 levels, rescues impairments of mitochondrial motility and neurite outgrowth. PH-002 is an apoE4 structure corrector that reverses the apoE4 detrimental effects.
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction; apoE4 structure corrector.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000064466
0000050781
0000050780
082M4616V

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