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Merck
CN

SML0474

(S)-Duloxetine hydrochloride

≥98% (HPLC), 5-HT and NA reuptake inhibitor, powder

Synonym(s):

(γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, LY-248686 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H19NOS · HCl
CAS Number:
136434-34-9
Molecular Weight:
333.88
UNSPSC Code:
12352200
PubChem Substance ID:
329825429
NACRES:
NA.77
MDL number:
MFCD06407958

Key Documents

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Product Name

(S)-Duloxetine hydrochloride, ≥98% (HPLC)

SMILES string

Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3

InChI

1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1

InChI key

BFFSMCNJSOPUAY-LMOVPXPDSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +116 to +125°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL (clear solution, warmed)

storage temp.

room temp

Quality Level

100

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

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Application

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

Biochem/physiol Actions

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI), widely used clinically as an antidepressant and anxiolytic.
Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI); antidepressant; anxiolytic.

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Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000303059
0000303059
0000298392
0000298392
0000222050

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A review of duloxetine 60 mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic osteoarthritis pain and low back pain
Pergolizzi Jr JV, et al.
Pain Practice : The Official Journal of World Institute of Pain, 13(3), 239-252 (2013)
Mechanisms of pain transmission and pharmacologic management
Argoff C
Current Medical Research and Opinion, 27(10), 2019-2031 (2011)
High-performance liquid chromatographic method for the simultaneous estimation of the key intermediates of duloxetine
Soni P, et al.
Talanta, 67(5), 975-978 (2005)
Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats
Martin-Hernandez D, et al.
Neuropharmacology, 103(3), 79-91 (2016)
Prasad B Phapale et al.
Bio-protocol, 11(21), e4214-e4214 (2021-12-04)
Expanding our understanding of drug-gut bacteria interactions requires high-throughput drug measurements in complex bacterial cultures. Quantification of drugs in the cultures, media, and cell pellets is prone to strong matrix effects. We have developed a liquid chromatography-high resolution mass spectrometry
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