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SML0481

Qc1

≥98% (HPLC)

Synonym(s):

1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C23H16F3N3O2S
CAS Number:
403718-45-6
Molecular Weight:
455.45
NACRES:
NA.77
PubChem Substance ID:
329825432
UNSPSC Code:
12352200
MDL number:
MFCD02649259
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution, warmed)

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cccc(c1)N2C(=S)Nc3cc(ccc3C2=O)C(=O)NCc4ccccc4

InChI

1S/C23H16F3N3O2S/c24-23(25,26)16-7-4-8-17(12-16)29-21(31)18-10-9-15(11-19(18)28-22(29)32)20(30)27-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,27,30)(H,28,32)

InChI key

IFNVTSPDMUUAFY-UHFFFAOYSA-N

Biochem/physiol Actions

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH).
Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC50 value for inhibition of TDH by Qc1 is 500 nM, with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC50 of 3 mM.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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