SML0499
NCTT-956
≥97% (NMR)
Synonym(s):
N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide
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About This Item
Empirical Formula (Hill Notation):
C17H15N3O4S
CAS Number:
Molecular Weight:
357.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥97% (NMR)
Form:
powder
Quality Segment
assay
≥97% (NMR)
form
powder
color
light orange to dark orange
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
2-8°C
SMILES string
CCC(=O)NC(c1cccs1)c2cc([N+]([O-])=O)c3cccnc3c2O
InChI
1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21)
InChI key
DEXNORPUTBBNSC-UHFFFAOYSA-N
Biochem/physiol Actions
NCTT-956 is a potent, specific 12-LO inhibitor.
NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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