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SML0505

Tienilic Acid

Name: Tienilic Acid
Brand: SIGMA

≥98% (HPLC), P450 inhibitor, powder

Synonym(s):

Ticrynafen, Tienylic acid, [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₈Cl₂O₄S

CAS Number:

40180-04-9

Molecular Weight:

331.17

NACRES:

NA.77

PubChem Substance ID:

329825452

UNSPSC Code:

12161501

EC Number:

254-826-3

MDL number:

MFCD00867339

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Tienilic Acid, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(=O)COc1ccc(c(Cl)c1Cl)C(=O)c2cccs2

InChI

1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)

InChI key

AGHANLSBXUWXTB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity.

Tienilic Acid is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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