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SML0540

Oxyphenbutazone

Name: Oxyphenbutazone
Brand: SIGMA

≥98% (HPLC), non-steroid anti inflammatory drug, powder

Synonym(s):

p-Oxyphenylbutazone, 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione, G 27202, NSC 526053, Ro 04-4410, p-Hydroxyphenylbutazone

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₀N₂O₃

CAS Number:

129-20-4

Molecular Weight:

324.37

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Oxyphenbutazone, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

N2(N(C(=O)C(C2=O)CCCC)c3ccccc3)c1ccc(cc1)O

InChI

1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3

InChI key

HFHZKZSRXITVMK-UHFFFAOYSA-N

Description

General description

Oxyphenbutazone is a derivative compound of phenylbutazone.

Biochem/physiol Actions

Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent. Oxyphenbutazone is known to cause inflammatory effects on tissues. Oxyphenbutazone, as a drug, decreases cellular exudates, without involving the pituitary-adrenal axis or the immunity response. Though the drug delivers a number of side effects, it is considered to be less toxic than phenylbutazone, due to decreased rate of intestinal absorption.

Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent.

Oxyphenbutazone is an NSAID that has been shown to preferentially kill non-replicating Mycobaterium tuberculosis maintained in media that simulates the mildly acidic, in vivo conditions where drug-resistant, non replicating subpopulations of the bacteria reside in hosts. The compound has little or no affect on replication M. tuberculosis grown in normal liquid cultures.

Other Notes

Air sensitive

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H400

pcodes

P273 - P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000498392

0000498394