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SML0560

BRACO19 hydrochloride

≥96% (HPLC), powder, telomerase inhibitor

Synonym(s):

N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C35H43N7O2 · xHCl
CAS Number:
1177798-88-7
Molecular Weight:
593.76 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825553
NACRES:
NA.77
MDL number:
MFCD23380200
Assay:
≥96% (HPLC)
Form:
powder
Storage condition:
desiccated
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Product Name

BRACO19 hydrochloride, ≥96% (HPLC)

assay

≥96% (HPLC)

form

powder

storage condition

desiccated

color

yellow to brown

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1

InChI

1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H

InChI key

MJAPNWJRLLDPAB-UHFFFAOYSA-N

Application

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).

Biochem/physiol Actions

Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment. BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).
BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.
BRACO19 stabilizes G-quadruplexes; telomerase inhibitor.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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